Publications

Antibacterial Activity of Substituted Dibenzo[a,g]quinolizin-7-ium Derivatives.

Published In: Bioorganic and Medicinal Chemistry Letters2012 Download

Antibacterial Activity of Substituted 5-Methylbenzo[c]phenanthridinium Derivatives.

Published In: Bioorganic and Medicinal Chemistry Letters2012 Download

A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization.

Published In: Journal of Medicinal Chemistry2012 Download

Phenyl-Substituted 6,7-Dimethoxyisoquinoline Derivatives as FtsZ-Targeting Antibacterial Agents.

Published In: Bioorganic and Medicinal Chemistry2012 Download

Antimicrobial Activity of Various 4- and 5-Substituted 1-Phenylnaphthalenes.

Published In: European Journal of Medicinal Chemistry2013 Download

Substituted 1,6-Diphenylnaphthalenes as FtsZ-Targeting Antibacterial Agents.

Published In: Bioorganic and Medicinal Chemistry Letters2013 Download

Antibacterial Activity of Quinoxalines, Quinazolines, and 1,5-Naphthyridines.

Published In: Bioorganic and Medicinal Chemistry Letters2013 Download

TXA497 as a Topical Antibacterial Agent: Comparative Antistaphylococcal, Skin Deposition, and Skin Permeation Studies with Mupirocin.

Published In: International Journal of Pharmaceutics2014 Download

Enterococcal and Streptococcal Resistance to PC190723 and Related Compounds: Molecular Insights from a FtsZ Mutational Analysis.

Published In: Biochimie2013 Download

An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy in Vivo.

Published In: Antimicrobial Agents and Chemotherapy2013 Download

Pharmacokinetics and in Vivo Antistaphylococcal Efficacy of TXY541, a 1-Methylpiperidine-4-Carboxamide Prodrug of PC190723.

Published In: Biochemical Pharmacology2013 Download

Inhibition of RND-Type Efflux Pumps Confers the FtsZ-Directed Prodrug TXY436 with Activity against Gram-Negative Bacteria.

Published In: Biochemical Pharmacology2014 Download

TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.

Published In: Antimicrobial Agents and Chemotherapy2015 Download

In Vivo Pharmacodynamic Evaluation of an FtsZ Inhibitor, TXA-709, and Its Active Metabolite, TXA-707, in a Murine Neutropenic Thigh Infection Model.

Published In: Antimicrobial Agents and Chemotherapy2015 Download

Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus

Published In: Antimicrobial Agents and Chemotherapy2016 Download

Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ

Published In: ACS Chemical Biology 2017 Download